Today, Karmella Haynes from Arizona State University presented Synthetic chromatin in human cells. She is a returning to CSHL Synthetic Biology as a previous instructor and as one of the founders of the course (2013).
Her research group aims to determine how nuclear proteins from the “chromatin” system can be harnessed for synthetic biology applications. She developed a novel transcription activator that regulates genes through interaction with a cancer-associated epigenetic mark instead of through DNA-binding, which can become mutated in cancer.
In the future, she wants to teach a module on chromatin protein engineering and help budding synthetic biologists learn bioinformatics to determine how synthetic systems affect thousands of genes in human cells.