Day 6: The industrialization of biology

Written by: Karmella Haynes.

Andy Ellington from the University of Texas at Huston, presented an overview of current industries for DNA synthesis on-demand. His lab houses its own DNA synthesis system for the production of short oligonucleotides and the validation of correct sequences. Andy even offered on-demand production of genes for future CSH synthetic biology courses.

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Andy went on to discuss approaches to protein design, via software and with wet bench techniques. Rosetta is a software suite that aids protein structure prediction, guided by empirical biochemical information about natural proteins. A community of Rosetta users exchange information and collaborate over a website called Rosetta Commons. Andy explained his lab’s clever directed evolution strategy that enables the discovery and amplification of proteins with a function of interest.

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